Tag Archives: outreach

Infection Interruption: Identifying Compounds that Disrupt HIV

Know the enemy

Comparing microbial extracts with Dr. Sandra Loesgen.

The Human Immunodeficiency Virus, or HIV, is the virus that leads to Acquired Immunodeficiency Syndrome (AIDS). Most of our listeners have likely heard about HIV/AIDS because it has been reported in the news since the 1980s, but our listeners might not be familiar with the virus’s biology and treatments that target the virus.

  • HIV follows an infection cycle with these main stages:
    • Attachment – the virus binds to a host cell
    • Fusion – the viral wall fuses with the membrane of the host cell and genetic material from the virus enters the host cell
    • Reverse transcription – RNA from the virus is converted into DNA via viral enzymes
    • Integration – viral DNA joins the genome of the host cell
    • Reproduction – the viral DNA hijacks the host cell activity to produce more viruses and the cycle continues
  • Drug treatments target different stages in the HIV infection cycle to slow down infection
  • However, HIV has adapted to allow mistakes to occur during the reverse transcription stage such that spontaneous mutations change the virus within the host individual, and the virus becomes tolerant to drug treatments over time.

Faulty Machinery

Due to the highly mutable nature of HIV, a constant supply of new drug treatments are necessary to fend off resistance and treat infection. Our guest this week on Inspiration Dissemination, Ross Overacker a PhD candidate in Organic Chemistry, is screening a library of natural and synthetic compounds for their antiviral activity and effectiveness at disrupting HIV. Ross works in a Natural Products Lab under the direction of Dr. Sandra Loesgen. There, Ross and his lab mates (some of whom were on the show recently [1] [2]) test libraries of compounds they have extracted from fungi and bacteria for a range of therapeutic applications. Ross is currently completing his analysis of a synthetic compound that shows promise for interrupting the HIV infection cycle.

“Uncle Ross” giving a tour of the lab stopping to show off the liquid nitrogen.

Working in Lab with liquid nitrogen.

 

 

 

 

 

 

 

Havin’ a blast

Chemistry Club at Washington State University (WSU) initially turned Ross onto chemistry. The club participated in education outreach by presenting chemistry demonstrations at local high schools and club events. Ross and other students would demonstrate exciting chemistry demos such as filling hydrogen balloons with salt compounds resulting in colorful explosions piquing the interest of students and community members alike. Ross originally made a name in

Collecting Winter Chanterelles in the Pacific Northwest.

WSU’s chemistry club, eventually becoming the president, by showing off a “flaming snowball” and tossing it from hand to hand—don’t worry he will explain this on air. For Ross, chemistry is a complicated puzzle that once you work out, all of the pieces fall into place. After a few undergraduate research projects, Ross decided that he wanted to continue research by pursing a PhD in Organic Chemistry at Oregon State University.

 

 

Tune in this Sunday October 7th at 7 PM to hear from Ross about his research and path to graduate school. Not a local listener? Stream the show live or catch this episode on our podcast.

Comunicación Científica con Franco

Kristen Finch interviewing Francisco Guerrero for this special episode. (Photo by Adrian Gallo)

This week on Inspiration Dissemination we will be featuring a previous guest: Francisco Guerrero, a PhD student in the Department of Forest Engineering, Resources, and Management. Francisco’s first interview aired on October 18, 2015, and we called him back for a follow-up because he has been selected for the American Association for the Advancement of Science (AAAS) Mass Media Science and Engineering Fellowship. As a fellow, Franco will be writing feature stories about climate change and health for CNN en Español. Part of the fellowship will involve helping with film production, as well. FUN FACT last time Franco was on the show, he told us that he always wanted to be a movie producer. Franco will take this amazing opportunity during the final push for his PhD research to enhance his science communication skills and gain experience in production and video broadcasting.

This special interview will begin at 6:30 pm on May 6, 2018. We will be asking Franco about the application process, his responsibilities as a fellow, and his goals for the fellowship. After our interview with Franco, we will rebroadcast his first interview on Inspiration Dissemination at 7 pm.

Tune in to KBVR Corvallis 88.7 FM at 6:30 pm to hear about the AAAS Fellowship and learn about Franco’s research in the College of Forestry. Not a local listener? No sweat! Stream the show live on line or hear the podcast next week.

Franco wants to hear from you! Tweet him with ideas for CNN Español, specifically stories about Climate Change and Health. 

The folks behind the episode: Francisco Guerrero, Kristen Finch, and Lillian Padgitt-Cobb. (Photo by Adrian Gallo)