This is one of the most common enzymes found in the cytochrome P450 mixed-function oxidase system, called CYP3A4. The P450 family of proteins is responsible for the metabolism of various compounds within the body such as drugs. CYP3A4 is a really good model enzyme for this system because it is abundant in the liver where almost all detoxification occurs, however it is also found in the brain and other organs as well. This picture clearly shows the complex form of this protein and also gives a good view of the heme prosthetic group in the middle. This enzyme is the foundation for why toxic compounds do not build up in the body when pharmaceuticals are introduced.
Protein artists
- 2010 Protein Portraits in the news
- Alissa Eckert
- Bathsheba Grossman
- Byron Rubin
- David Goodsell
- Drew Berry
- Gael McGill
- Irving Geis
- Jane Richardson
- Janet Iwasa
- Jenny Langley
- Julian Voss-Andreae
- Mara Haseltine
- Maria Winners infectious art
- Mike Tyka
- Protein art by May_k
- Steve Miller
- Wunderkammer crochet
Protein science
- AlphaFold
- AlphaFold: How to predict structures
- AlphaFold: Tutorial
- David Goodsell's Molecule of the Month
- Domain classification: CATH
- Domain classification: SCOP
- Folding at home
- Foldit
- Jane Richardson modeling
- Perkins: History of Molecular Representation Part 2
- Protein Spotlight (SIB)
- RCSB PDB: Search the protein databank
Studio tricks and materials
Viral artistry
- 2015 Year of the Phage
- Ann Kiernan for The Washington Post
- Bad news wrapped in protein
- Corona virus mandala
- Goodsell CoV-2
- Illustration by Nicholas Konrad
- SARS-CoV-2 Spike Glycoprotein- 2D illustration
- SARS-CoV-2 Spike Glycoprotein-Macarroni models
- SARS-CoV-2 spike protein models, space filling, by David Veesler
- Sean McSorley, Virosphere illustration
- The Spiky Blob Seen Around the World
Weekly topics
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