“To study the phenomenon of disease without books is to sail an uncharted sea, while to study books without patients is not to go to sea at all.“Sir William Osler (1849 – 1919)
Celebrating Linus Pauling Day
In celebration of Linus Pauling Day, Dr. van Breemen was interviewed by Dr. John Westerdahl on LifeTalk Radio.
Linus Pauling is one of the most famous scientists born and raised in Oregon. February 28th is Linus Pauling’s birthday, which the Governor declared as a local holiday in the state of Oregon.
Linus Pauling was a career long academician and teacher, and it is the mission of the Linus Pauling Institute to train the next generation of scientists in the prevention of diseases of aging – a tradition that Pauling created with this Institute. The full interview is available for download.
- Dr. John Westerdahl is a nutritionist and board certified anti-aging health practitioner. He is also the radio host for the program Health & Longevity.
A landmark literature of 2019 featured in The Analytical Scientists magazine
When Luying was developing an assay to study how botanical dietary supplements may affect drug metabolism, she identified and reported a widespread presence of drugs in samples of “supposedly” pure human serum. These include: caffeine, alprazolam (an anti-anxiety medicine), and dextromethorphan (an cough suppressant).
The Truth About TransfusionsDr. Catherine Fenselau, Distinguished University Professor Emeritus, University of Maryland
Her measurements were made following FDA guidance for pharmacological studies, using stable isotope labeled internal standards and ultrahigh performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) on a Shimadzu triple quadrupole mass spectrometer.
She tested 18 lots of human serum from North American sources – all of which contained caffeine (as high as 250 ng/mL), 13 contained alpraxolam, and 8 contained dextromethorphan. Two individual donors had to be recruited to abstain from caffeinated foods and beverages to complete her assay validation.
- article from The Analytical Scientist magazine
- featured landmark paper by Luying Chen and Dr. Richard van Breemen.
Validation of a sensitive UHPLC-MS/MS method for cytochrome P450 probe substrates caffeine, tolbutamide, dextromethorphan, and alprazolam in human serum reveals drug contamination of serum used for research.
J Pharm Biomed Anal. 2020 Feb 5;179:112983. doi: 10.1016/j.jpba.2019.112983