It Takes Two to Tango: A Second Type of Neurotrophin

One Response to It Takes Two to Tango: A Second Type of Neurotrophin

1. rogersa says:

   April 15, 2009 at 1:44 pm

   Scorecard:

   Title NEUROTROPHIN 4 (HOMODIMER)
   Authors Robinson, R.C., Radziejewski, C., Stuart, D.I., Jones, E.Y., Choe, S.
   Primary Citation Robinson, R.C., Radziejewski, C., Spraggon, G., Greenwald, J., Kostura, M.R., Burtnick, L.D., Stuart, D.I., Choe, S., Jones, E.Y. (1999) The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site. Protein Sci. 8: 2589-2597
   [ Abstract ] View PubMed Abstract at NCBI
   History Deposition 1999-02-22 Release 1999-02-26
   Last Modified (REVDAT) 2009-02-24
   Experimental Method Type X-RAY DIFFRACTION Data N/A
   Parameters
   Resolution[Å] View a histogram of Resolution R-Value R-Free Space Group
   2.75 0.235 (obs.) 0.336 P 21 (P 1 21 1)
   Unit Cell
   Length [Å] a 43.80 b 50.80 c 53.00
   Angles [°] alpha 90.00 beta 109.40 gamma 90.00
   Molecular Description Asymmetric Unit
   Polymer: 1
   Molecule: PROTEIN (NEUROTROPHIN-4) Chains: A, M type: polypeptide(L) length: 130
   Fragment: precursor residues 81-210

   Structure Weight: 27924.85
   Classification Hormone/growth Factor
   Source
   Polymer: 1 Scientific Name: Homo sapiens Go to NCBI Taxonomy entry Common Name: Human Expression system: Escherichia coli
   Ligand Chemical Component

   Identifier Name Formula Ligand Expo Drug Similarity Hapten Similarity Ligand Structure 3D-Ligand Interaction
   CL CHLORIDE ION Cl Link out to Ligand Expos:CL Link out to SuperLigands:CL Link out to SuperHapten:CL [ View ] [ View ]
   SCOP Classification (version 1.73)
   Domain Info Class Fold Superfamily Family Domain Species
   d1b98a_ Small proteins Cystine-knot cytokines Cystine-knot cytokines Neurotrophin Neurotrophin 4, NT4 Human (Homo sapiens) [TaxId: 9606]
   d1b98m_ Small proteins Cystine-knot cytokines Cystine-knot cytokines Neurotrophin Neurotrophin 4, NT4 Human (Homo sapiens) [TaxId: 9606]
   CATH Classification (version v3.2.0)
   Domain Class Architecture Topology Homology
   1b98A00 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines
   1b98M00 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines
   PFAM Classification
   Chain PFAM Accession PFAM ID Description Type Clan ID
   A PF00243 Link out to PFAM:PF00243 NGF Nerve growth factor family Domain
   M PF00243 Link out to PFAM:PF00243 NGF Nerve growth factor family Domain
   GO Terms
   Polymer Molecular Function Biological Process Cellular Component
   PROTEIN (NEUROTROPHIN-4) (1B98:A,M)

   * receptor binding * growth factor activity * regulation of synaptic plasticity * extracellular region