So what’s all this business about A2 milk?  How is it different from A1 milk?  Is it hooey?  What do these codes refer to anyway?

Starting with the last question first, A1 and A2 refer to “versions” of the beta-casein gene. In this case, the gene in question encodes the protein beta-casein, one of three casein proteins, which is, of course, a key component of cheese. The A2 version of this protein varies just a little bit in its structure from the A1 version. An individual cow’s genotype could be A1A1, A2A2, or A1A2 for the beta-casein gene; her milk would then contain whichever protein versions her genes dictate.

The a2 Milk Company claims that A2-only milk is easier on digestion. A recent study has suggested that in milk-sensitive individuals, milk containing A1 protein may be associated with symptoms of discomfort after milk consumption, and with strictly A2 milk those symptoms may be lessened. Also, gastrointestinal transit time appears to be slower with A1 milk consumption but, contrarily, yielding softer stools. Additional studies to provide replication of these findings are needed. Early studies on A1 and A2 milk that suggested a link between A1 milk and several diseases have been unsupported by subsequent investigations. That is, there is no evidence that consuming milk containing A1 protein carries any disease risk.

So, should breeding decisions be made on the basis of beta-casein genotype? Or perhaps the question is, is A2 milk a fad or a legitimate, long-term slice of the market? Does A1 vs. A2 matter for yogurt or cheese making? There is a lot we still don’t know about the biology of milk. However, there would seem to be little risk in choosing A2A2 bulls. There are quite of few of them out there, although the number varies by breed. The most comprehensive and recent documentation of beta-casein genotype by breed has been compiled by the Canadian Dairy Network (see table).

Available data from U.S. cattle are more limited in number and over 20 years old. Interestingly, Zebu- or Brahman-type cattle have a very high frequency of A2A2.

Bottom line, don’t compromise your primary genetic objectives for your herd just to chase an A2A2 genotype, but there’s likely no harm in moving that direction if it makes sense for your market of the future.

For a deeper dive into the biology of A1 and A2, read on.

A1 and A2 refer to types of gene variants of the beta-casein gene. A gene variant (an allele, for those who remember their biology) is when we have a difference in the DNA sequence for a particular gene. The A2 gene variant encodes a proline (a particular amino acid; you’ll recall that amino acids are the building blocks of proteins) at position 67 in the 209-amino acid chain that forms beta-casein (see figure below). The A1 gene variant encodes a histidine at position 67.

The A1 beta-casein protein is thought likely to be cleaved (cut) during gastrointestinal digestion at the position 67 histidine, while A2 beta-caseins are less likely to be cleaved there. Cleavage at amino acid 67 generates a short protein (a peptide) called beta-casomorphin-7 (abbreviated BCM7). BCM7 has opioid properties. Now, no need for concern. We all know that while milk is tasty, it is not a very effective painkiller nor brain manipulator. It is possible though, that BCM7 may have some effect on processes in the gut, such as slowing the rate of passage. Also, all milk contains additional types of opioid peptides. Other foods (from animals and plants) do as well.

 

Diagram shows cartoon of regions of beta-casein protein with variable amino acid indicated.
The region of the beta-casein protein where A1 and A2 vary.

Are too many heifers on your farm showing up with mastitis early in that first lactation? You may want to examine your prevention strategies. A review paper that examined the effectiveness of various precalving treatments in heifers was published earlier this summer. Here are the key take-a-ways:

developing udder on a Jersey heifer
She’ll be in the parlor soon.
photo: Spirited Rose Homestead Dairy Farm
  • When the infection is caused by contagious bacteria (e.g., Streptococcus agalactiae, Staphylococcus aureus), antibiotics, teat sealants, and vaccines can improve udder health outcomes.
  • Particularly if you are considering using antimicrobial treatments, culture quarter milk so you know who the enemy is. We want to minimize the development of antibiotic resistance.
  • When environmental pathogens (e.g., Escherichia coli, non-agalactiae streptococci) are the problem, teat sealants and combination therapies are effective at reducing mastitis risk.
  • When coagulase-negative staphs (CNS) are infecting heifer udders, antibiotics, teat-sealants, and combination therapies offer the most help.
  • When employing any of these treatment options, be sure they are delivered by a well-trained person.
  • On farms with effective fly control and that minimize stress for late-gestation heifers, there may be little benefit from preventative medical treatment.

The paper: Naqvi, Nobrega, Ronksley, & Barkema. June 2018. Effectiveness of precalving treatment on postcalving udder health in nulliparous dairy heifers: A systematic review and meta-analysis. Journal of Dairy Science 101:4707-4728.

Another good resource is the National Mastitis Council’s Heifer Mastitis Prevention and Control Plan.

Researchers from Oregon State University investigated the blood serum profiles of Holstein cows before and after calving and compared those that developed clinical mastitis with those that did not. To do so, they used ultra-performance liquid chromatography high resolution mass spectrometry plus statistics to identify differences in concentration of metabolites, lipids, minerals, and inflammatory markers in blood serum. It’s OK if you read that last sentence and went, “Huh?”  The short version is that they ran blood serum samples from dry cows through some fancy laboratory equipment to see if there were any indicators associated with developing clinical mastitis after calving. And yes, there are!

For example, alpha-tocopherol (a form of vitamin E) levels were significantly higher in the blood of cows that did not develop clinical mastitis compared to those that did (Figure 1). Another difference was in the overall profile of metabolites (molecules that participate in or are produced during metabolism); they were quite different for cows that remained healthy and those with post-calving mastitis (Figure 2).

Figure 1. Control animals (no mastitis; open bars) had significantly more alpha-tocopherol (vitamin E) in their blood than cows that developed mastitis (shaded bars). From Figure 4 from Zandkarimi et al. 2018.
The figure shows self-organizing map of metabolomic data.
Figure 2. See the starkly different profiles in serum metabolite concentration between cows that developed mastitis post-calving (CMP) and those that did not (Control)? The metabolites are grouped by metabolite family, e.g., carnitines. The more red colors indicate higher concentrations, while blue indicates lower. From Figure 5 from Zandkarimi et al. 2018.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

While no dairies have liquid chromatography mass spec technology in their on-farm lab, these results may lead the way to identifying one or two highly reliable blood markers that could be easily measured on the dairy. And forewarned is forearmed, right? Knowing which cows were likely to develop mastitis could allow proactive treatment to prevent the more expensive and damaging clinical mastitis.

The paper: F. Zandkarimi, J. Vanegas, X. Fern, C.S. Maier, G. Bobe. Metabotypes with elevated protein and lipid catabolism and inflammation precede clinical mastitis in prepartal transition dairy cows. Journal of Dairy Science, June 2018, 101:5531–5548

Significant chanImage of the logo for the Margin Protection Programges to the Margin Protection Program for dairy producers were made in the Bipartisan Budget Act of 2018.  The Farm Service Agency has recently announced new implementation rules to accommodate the changes.  Mark Stephenson and Andrew Novakovic, from the University of Wisconsin and Cornell University, will conduct a webinar to walk you through these changes and to assess impacts on producers who participate.

The webinar will be hosted by Farm Credit East at 10:00 AM PDT on Monday, April 9. It will be limited to the first 500 registered attendees.  You can register for the webinar at https://DairyMarkets.org/register/  The webinar will be recorded and made available as an online stream after it is presented live.

Oregon Junior Holstein Sale

 

5 Holstein heifers & 1 Brown Swiss heifer selling.

Open to all interested 4H & FFA members.

The Sale Catalog is available on Facebook (https://www.facebook.com/oregonjuniorholsteinassociation/), in pdf form here: Junior Holstein Sale Catalog 2018, or can be mailed upon request.

The sale is April 7, 2018, starting at noon, at

Meadowood Dairy

4900 Cook RD SE

Turner, OR 97392

Any questions: 503-559-7222 Megan; 503-932-7129 Brian

***No pets

The Oregon State University Dairy Club is hosting its bi-annual

Beaver Dairy Youth Day

on Saturday, April 14, 2018

from 9:00-4:00,

at the OSU Dairy,

for kids in grades 4-12.

Dairy club members, along with industry experts, will be teaching youth about dairy judging and pedigree reading. After lunch, there will be a dairy judging competition for all levels of experience. Cattle for the event will be provided by the OSU Dairy. Lunch and snacks will be provided. However, if a student requires a special diet, please bring it from home. Event t-shirts, lunch, and awards are all included in the cost. Please preregister by March 28. Click on the link below for the registration form and additional information.

Beaver Dairy Youth Day form 2018

Join the Polk SWCD staff as they host forage seed growers from our region to learn about the many seed resources grown in our region.  Livestock and horse owners will learn about the many grass, legume, and other kinds of seed available for high quality forage production.  Factors such as suitability to soil type and moisture, hardiness, and livestock dietary need will be discussed by our panel of growers and seed company representatives. Bring a tag from a pasture seed mix bag or other list for discussion.

RSVP  by February 20  to Claudia.Ingham@PolkSWCD.com or 503-623-9680 ext. 101 to ensure your light dinner at 5pm.

February 22, 2018       5-7pm

Polk County Fairgrounds, Building B

520 S Pacific Hwy W, Rickreall, OR 97371

A cow in an automated milking unit.
All teat cups still on so far.

Swedish researchers shaved one minute off milking times in an automated milking system (robot) when they increased the setting for milk flow at take-off from 0.06 kg/min (0.13 lb/min) to 0.48 kg/min (1.06 lb/min). Well yeah, you’re thinking, of course it would. These researchers also measured milk composition, harvested milk yield, and the amount of residual milk left in the udder. And none of those things was significantly different between the take-off milk flow rates. (They also looked at a take-off flow level of 0.3 kg/min [0.66 lb/min]).

A similar study was conducted in New Zealand, where researchers looked at 0.2, 0.4, 0.6, and 0.8 kg/min (0.44, 0.88, 1.3, and 1.8 lb/min, respectively) milk flow rates for determining take-off. Here, the cows were milked in a rotary parlor, and take-off flow rates were for the unit rather than by quarter. They, too, found no differences in milk yield or milk composition.

So, you may want to check the minimum milk flow settings on your automatic takeoffs. Bumping that number up should decrease individual milking times without sacrificing milk production or altering composition. Getting cows through the robot faster is good for pounds of milk per robot. And who’s going to complain if (parlor) milking finishes a little earlier?

the articles:

Krawczel et al. 2017. Milking time and risk of over-milking can be decreased with early teat cup removal based on udder quarter milk flow without loss in milk yield. Journal of Dairy Science 100:6640–6647.

Edwards et al. 2013. Milking efficiency for grazing dairy cows can be improved by increasing automatic cluster remover thresholds without applying premilking stimulation. Journal of Dairy Science 96:3766–3773.

Artificial Insemination in Dairy Cattle

This three-day program includes both indoor and outdoor instruction and practice on the skill of artificial inseminating cows. The class also provides instruction on cow and herd management for efficient, successful reproduction. A certificate of achievement is given upon successful completion of the course.

Young Calf Health Workshops

Best Management Practices for Young Calves  (December 1, 2017, 1-4 pm)

Interventions for Sick Calves  (December 8, 2017, 1-4 pm)

Classroom and hands-on instruction at OSU in Corvallis.

For more detailed information, click to open the flier:

young calf health workshop flier 2017.12

To register, go to http://bit.ly/MarionDairyWorkshops