Congrats to College of Science postdoc, Isabelle Logan on her Fellowship with the Children’s Tumor Foundation.
Signaling pathways regulated by nitrated proteins as novel therapeutic targets for neurofibromatosis type 2
Nitrated proteins are a novel category of NF2 tumor targets as they play a key role in schwannoma growth and are not present in normal cells. The goals of this project are to investigate the regulation of signaling pathways by nitration and to identify the specific nitrated protein(s) that support NF2 tumor cell survival. Besides NF2, these proteins could be new targets in conditions such as glioblastoma, breast cancer, and colon cancer, where protein nitration is involved in proliferation.