Blakemore Research Group

Puzzle Night

NMR structure elucidation puzzles

Problems were acquired from UC Irvine’s Professor James S. Nowick’s Organic Spectroscopy course, full site with all problems can be found here.

Problem 1 : Molecular formula C₁₅H₂₂O₂

Problem 2 : Molecular formula C₁₆H₂₂O

Problem 3 : Molecular formula C₁₀H₁₆O

Note: There were no answers provided for these questions

Target: Eliseo

Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A and B

Method: Bryce

http://Insert link

Natural Product Retrosynthesis Activity

We will devise a retrosynthetic analysis of the natural product and propose a plausible forward route to the core. We will visit the publication next week during group meeting.

Target: Kik

Total Synthesis of Resiniferatoxin

Method: Layhna

DABCO-Catalyzed Reaction of 2-Naphthols with Aryl Isothiocyanates: Access to 2-Iminonaphtho-1,3-oxathioles

Target: Yang

Total Synthesis of Bipolamine I

Method: Blaik

Enantioselective Cobalt-Catalyzed Hydroboration of Fluoroalkyl-Substituted Alkenes to Access Chiral Fluoroalkylboronates

Target: Yang

[Link] Total Synthesis of Bipolamine I

Method: Blaik

Postponed

Spotlight: Layhna

Darren Dixon (University of Oxford)
Special Topic: One-Pot Catalytic Enantioselective Synthesis of 2-Pyrazolines

Target: Eliseo

Symmetry-Driven Total Synthesis of Myrioneurinol

(Method skipped)

Spotlight: Bryce

[Profile name / Research update; optional — upload slides as PDF]

Target: Blaik

Asymmetric Total Synthesis of (−)-Phaeocaulisin A

Method: Layhna

Undirected, Asymmetric Alkyl Group Functionalizations through Alkane Dehydrogenation

Spotlight: Yang

[Profile name / Research update; optional — upload slides as PDF]

Target: Kik

Asymmetric Total Syntheses of Cephalotane-Type Diterpenoids Cephanolides A–D

Method: Bryce

Highly Regio-, Stereo-, and Enantioselective Copper-Catalyzed B−H Bond Insertion of α-Silylcarbenes: Efficient Access to Chiral Allylic gem -Silylboranes

 

Spotlight: Eliseo

[Profile name / Research update; optional — upload slides as PDF]