We have a new paper in Nature Communications! Using a combination of network biology and experimental validation, we were able to identify two species from the Lactobacillus genus that act upon mitochondria in the liver and improve lipid metabolism. We also found that glutathione may be an important mediator of these effects. Read our paper here.
Graphical abstract by Zoe Moulton
Congratulations to our PhD student, Nolan Newman, for receiving the Sponenburgh Graduate Travel Award
Nolan has received the Sponenburgh Graduate Travel Award for his research presentation at the OSU Graduate Student Virtual Symposium. This is a $1000 award that will be used to cover travel costs for national or international research conferences (when those resume following the end of the pandemic).
Paper accepted in Science!!!!
“Fecal Microbiota Transplant Overcomes Resistance to Anti- PD-1 Immunotherapy in Advanced Melanoma Patients” in collaboration with Trinchieri and Zarour labs with our former postdoc Richard Rodrigues and Andrey Morgun
Paper just accepted in Nature Communications!
Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet induced diabetes
Congratulations to our postdoc, Zhipeng Li, for his new postdoc position at the University of Chicago. Zhipeng has been in our lab for the last three years and has been an invaluable member of our research team, including being an author on multiple publications. He will absolutely be missed but we all wish him the best at his new university!
We have been quite busy recently!
Our PhD candidate, Manoj Gurung, has just received the Carson College of Veterinary Medicine graduate student award. Congrats, Manoj!
We also have recently published two more papers:
- Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ. Koscsó B, Kurapati S, Rodrigues RR, Nedjic J, Gowda K, Shin C, Soni C, Ashraf AZ, Purushothaman I, Palisoc M, Xu S, Sun H, Chodisetti SB, Lin E, Mack M, Kawasawa YI, He P, Rahman ZSM, Aifantis I, Shulzhenko N, Morgun A, Bogunovic M.Sci Immunol. 2020 Apr 10;5(46). pii: eaax0062. doi: 10.1126/sciimmunol.aax0062. PMID: 32276965
- Germ-Free Swiss Webster Mice on a High-Fat Diet Develop Obesity, Hyperglycemia, and Dyslipidemia. Logan IE, Bobe G, Miranda CL, Vasquez-Perez S, Choi J, Lowry MB, Sharpton TJ, Morgun A, Maier CS, Stevens JF, Shulzhenko N, Gombart AF. Microorganisms. 2020 Apr 5;8(4). pii: E520. doi: 10.3390/microorganisms8040520. PMID: 32260528
We’re in the news! In a large metastudy, we have identified common microbiota (both at the genera and species level) that are associated with type 2 diabetes. The review paper, Role of gut microbiota in type 2 diabetes pathophysiology has combined the results of 42 separate studies and the findings have been summarized in an article written by New Atlas. Check out the New Atlas article here or the review paper here.