We specialize in biomedical processes and technologies that involve biotransport phenomena, including:
(1) Stabilization of biomolecules, cells, tissues, and organs by cryopreservation or drying, with applications in pharmaceuticals, cell therapy, tissue engineering and organ transplantation.
(2) Microfluidic devices for processing biological fluids, with applications in blood purification and pathogen inactivation.
Featured Publications
Ahmadkhani N, Sugden C, Brown D, Drummond N, Snyder A, Uden M, Higgins AZ, A high throughput platform for measuring and predicting vitrification behavior in multicomponent aqueous solutions, bioRxiv, 2026.02.19.706831
Ahmadkhani N, Sugden C, Mayo AT, Higgins AZ, Screening for cryoprotective agent toxicity and toxicity reduction in mixtures at subambient temperatures. Cryobiology, 121: 105315, 2025.
Ahmadkhani N, Benson JD, Eroglu A, Higgins AZ. High throughput method for simultaneous screening of membrane permeability and toxicity for discovery of new cryoprotective agents. Scientific Reports, 15 (1); 1862, 2025
Warner RM, Yang J, Drake A, Lee Y, Nemanic S, Scott D, Higgins AZ. Osmotic response during kidney perfusion with cryoprotectant in isotonic or hypotonic vehicle solution. PeerJ. 2023 Nov 21;11:e16323. doi: 10.7717/peerj.16323. PMID: 38025736; PMCID: PMC10668850.
Gulieva RE, Higgins AZ. Human induced pluripotent stem cell derived kidney organoids as a model system for studying cryopreservation. Cryobiology. 2021 Dec;103:153-156. doi: 10.1016/j.cryobiol.2021.08.006. Epub 2021 Sep 1. PMID: 34478696.
Lahmann JM, Faase RA, Leu HY, Jacques SL, Scottoline B, Schilke KF, Baio JE, Higgins AZ. Microfluidic photoreactor to treat neonatal jaundice. Biomicrofluidics. 2021 Nov 24;15(6):064104. doi: 10.1063/5.0066073. PMID: 34853627; PMCID: PMC8616629.