Our current efforts are focused on the understanding how the interplay between host and microbiota contributes to health and disease. The key questions we are asking are: 1) Which components of microbiota (microbial taxa and genes) drive specific immune and other host functions; 2) Which of those mechanisms play role in diseases we study; 3) Do environmental and/or host factors alter microbiota in a manner that it acquires properties which are harmful or beneficial to the host?

Our research program consists of three core disease-oriented projects: enteropathy associated with common variable immunodeficiency, type 2 diabetes, and cervical cancer as well as several smaller projects concerned with the effects of specific perturbations such as antibiotics, arsenic, and knockout of a transcription factor Gata4 in the intestine (see Figure). Network analysis is a core project on its own, with a special role of providing essential analytical tools for the other projects

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