By Lisandra Santiago-Delgado, Project 5 Trainee

Lisandra Santiago-Delgado
Lisandra Santiago-Delgado

Earlier this summer I conducted research at the USEPA Robert S. Kerr Research Laboratory in Ada, Oklahoma under the guidance of Dr. Eva L. Davis. This experience was made possible through the KC Donnelly Externship Award Supplement that I received in late April.

Research Benefits

The main objective of my externship was to collaborate and learn from Dr. Davis, an expert in the field of thermal remediation of contaminated soils and groundwater. I focused on utilizing steam injections on a laboratory scale to thermally remediate creosote-contaminated Superfund soils.

Another goal of this externship was to understand the chemical processes that occur during and after remediation. I looked at measurements of polycyclic aromatic hydrocarbons (PAHs) and their transformation to oxygenated PAHs (oxy- and hydroxy-PAHs) in soils, as well as their potential developmental toxicity and mutagenicity.

This partnership was a great fit, because it combined the expertise of Dr. Davis, involving thermal remediation of soil, with our expertise in soil analysis for PAHs and oxygenated PAHs, and toxicity assays in our SRP Project 3, directed by Dr. Robyn L. Tanguay.

Career Impact

The experimental setup used for one-dimensional steam injections.  It consists of two ISCO syringe pumps (left), steam generator (upper middle), column with soil sample (middle), and the computer to collect temperature data in the right.
The experimental setup used for one-dimensional steam injections. It consists of two ISCO syringe pumps (left), steam generator (upper middle), column with soil sample (middle), and the computer to collect temperature data in the right.

I have always considered a career path with the federal government.   This experience allowed me to experience first-hand what it would be like. Preparing to work in a federal facility was probably, and surprisingly, one of the greatest initial challenges of the project. It included paperwork, security clearance procedures, and training, among many other things.

Having the opportunity to meet, collaborate, and have one-on-one conversations with Dr. Davis was a fulfilling experience, especially since she is a female scientist. I also met other scientists working in the same facility, but base their research here in the Willamette Valley. Other experiences included participating in their weekly seminars, where they present trending topics of importance to the environment and the USEPA, as well as their own research updates.

Outside of research, weather was a big challenge, especially since my externship began in the middle of tornado season. One afternoon I had to spend over a half hour in a closet while the sirens were blaring. My next visit will be before May, for sure!

Summary

The externship was definitely an incredible experience, and it provided me with better understanding of thermal remediation and new knowledge about soil and how chemicals behave underneath the surface. I encourage other SRP trainees to apply for the KC Donnelly Externship Award Supplement. You will not regret it, and the outcome will be very valuable for your current research and future work as well.

The EPA provided a welcoming atmosphere and the OSU beaver was a nice touch.
The EPA provided a welcoming atmosphere and the OSU beaver was a nice touch.

SRP Trainee Mitra Geier was able to attend The International Neurotoxicology Association and Neurobehavioral Teratology Society joint meeting last month with her Externship Award from the SRP Training Core. The aim of the Externship Award is to support opportunities for SRP trainees that will provide enhanced experiential learning activities that benefit the trainee’s career goals.

Networking and face-time with peers and scientists is an essential part of an Externship opportunity.  At the conference, Mitra was able to interact and formalize her connections with other trainees from five different SRP centers across the country, including students whose work involved epidemiology, cell culture, fish, and mammalian model systems.  She will be reporting back to the OSU SRP trainees at their monthly meeting about what she learned from the other trainees at the conference related to their Superfund Centers, their activities, and their interests.

Mitra was also able to attend sessions and interact with leading scientists. She attended sessions to learn about different methods for assessing neurotoxicity, including mechanistic and behavioral effects, especially in the context of how the different models can be used to approach similar questions.   Mitra attended the sessions on neurotoxicants in air pollutants and inhaled particles, which are particularly relevant to her research. There was also sessions related to neurotoxicology screening studies and non-mammalian models of neurotoxicity including fish studies that were highly applicable to her screening work in zebrafish. The sessions on epigenetics and the microbiome were not directly related to her work, but she found them very useful in her long-term research interest development.

Mitra Geier
Mitra Geier

Mitra Geier is a PhD student working under Dr. Robyn Tanguay with Project 3: Systems Approach to Define Toxicity of Complex PAH Mixtures.

Mitra received her B.S. in Environmental Science from Western Washington University.  Her current research is focused on defining the developmental toxicity of parent and methylated PAHs, the neurobehavioral effects of these compounds during the embryonic stage and in adulthood, and the molecular pathways involved in these effects using the embryonic zebrafish model.

Chemistry graduate student Ivan Titaley has been immersed in polycyclic aromatic hydrocarbon (PAH) research within SRP Project 5 – Formation of Hazardous PAH Breakdown Products in Complex Environmental Mixtures at Superfund Sites under Dr. Staci Simonich.

Ivan Titaley
Ivan Titaley

Recently, Ivan was selected by Dr. Dayle Smith as a sponsored fellow at the Pacific Northwest National Laboratory (PNNL) to get hands-on training in modeling of polycyclic aromatic hydrocarbons. This program is through the Office of Science and Engineering Education (SEE) at PNNL. The selection is commendable, and will allow Ivan to apply new modeling techniquesl in his own research on OPAHs and OHPAHs transformation processes.

To financially support Ivan on this unique training opportunity, he has been awarded an SRP Trainee Externship Award through the SRP Training Core. This activity provides important synergy between Project 5 and Core C – Biostatistics and Modeling.

Dr. Smith will provide mentoring for Ivan to perform computational chemistry work to predict the formation of oxygenated-PAHs (OPAHs) and hydroxy-PAHs (OHPAHs) from higher molecular weight parent PAHs. More specifically, Ivan will be working using the NWChem 6.5 computational chemistry software. Using thermodynamic data on potential OH-PAH-adduct, he will be able to show which compounds will form based on thermodynamic stability.

Congratulations, Ivan!

 

Dr. David Williams was recently awarded the PANWAT Achievement Award at the 2014 Pacific Northwest Association of Toxicologist Meeting in Bothell, Washington on September 19.Screen Shot 2014-10-09 at 4.11.13 PM

Dr. Williams joined the faculty of the College of Agricultural Sciences in 1987 as an Assistant Professor, originally in Food Science and Technology, then transferring to the Department of environmental and Molecular Toxicology.

Over his 27 years on the faculty in the College of Agricultural Sciences, Dave emerged as an outstanding scholar, instructor and leader. He has been instrumental in developing new research programs or initiatives, most recently by leading the development of the OSU Superfund Research Program (SRP) Center application. Dave has also played a major role in identifying new faculty candidates, directing recruitment and especially mentoring new faculty who have joined EMT.

David is a nationally and internationally recognized leader in the fields of toxicology and carcinogenesis as evidenced by his role as peer reviewer for scientific manuscripts for many journals, especially through his leadership role as an Associate Editor of Toxicology and Applied Pharmacology for 10 years (arguably the top ranked toxicology journal in the world), and for which he has managed over 220 manuscripts to date.

He has also served as an interim Department Head of EMT, Center Director of two NIEHS-funded centers (Director of both the Superfund Research Program and Marine and Freshwater Biomedical Sciences Center at OSU). In addition, Dr. Williams has an outstanding record of leadership in the national scientific community, through his continuous participation as an invited reviewer by NIH in the peer review of research grant applications.

Two other faculty members of OSU Environmental and Molecular Toxicology have recently received this award ‐ Dr. Robyn Tanguay in 2012 and Dr. Nancy Kerkvliet in 2011.

(Adapted from story from Eddy Hall, NIEHS)

SRP Training Core Co-leader Stacey Harper has received the 2014 Savery Outstanding Young Faculty Award.

Stacey Harper
Stacey Harper

The Savery award is presented each year to a faculty member of the OSU College of Agricultural Sciences to recognize outstanding contributions through teaching, research, international, and/or extended education activities. Harper will receive the award, which includes a $1,000 cash prize and a plaque, at a faculty and staff luncheon Oct. 8.

Harper has been an outstanding role model for graduate students.  She was brought into the SRP Center as a leader when the Training Core was established in 2013.  She has been an assistant professor of nanotoxicology in the Department of Environmental and Molecular Toxicology (EMT) and the School of Chemical, Biological and Environmental Engineering since 2009.  Prior to joining the faculty at OSU, she was a postdoctoral fellow in the Environmental Health Sciences Center, where she was mentored by Robyn Tanguay, Ph.D (SRP Project 3 Leader and Center Research Coordinator).

Harper takes an integrative approach to studying the environmental, health, and safety impacts of nanotechnology. Her lab uses rapid assays to determine the toxic potential of nanomaterials, investigative tools to evaluate nanomaterial physiochemical properties, and informatics to identify the specific features of a nanomaterial that govern its environmental behavior and biological interactions.

In addition to her most recent honor, Harper was the 2012 recipient of the L.L. Stewart Faculty Scholars Award, which recognizes an outstanding faculty member at OSU with $30,000 in additional research support. Harper also received an Outstanding New Environmental Scientist (ONES) award from the National Institute of Environmental Health Sciences in 2011.

Earlier this summer, Harper received an NSF grant for nanomaterials research that begin next week.

Read more about Stacey Harper on her spotlight: Nanotechnology’s Gatekeeper within the Environmental Health Sciences Center web site.