Category Archives: Events

OSU Partners with PNNL for Biostatistics and Modeling Expertise

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Our Center is multi-investigator, multi-disciplinary and multi-institutional. In partnership with Pacific Northwest National Laboratories (PNNL), and other stakeholders and collaborators, we are developing new technologies to identify and quantitate known and novel polycyclic aromatic hydrocarbons (PAHs) found at many of the nation’s Superfund sites and assess the risk they pose for human health.

Women@Energy: Dr. Katrina Waters Photo credit: energy.gov
Women@Energy: Dr. Katrina Waters
Photo credit: energy.gov

The research projects in our Center collect large amounts of molecular and chemical data. This data includes measuring PAH mixtures in environmental samples, determining toxicity of PAH mixtures, and the mechanism(s) of action for these toxic endpoints.

Our Biostatistics and Modeling Core, lead by Dr. Katrina Waters, greatly enhances our Center by providing expert statistical and bioinformatics data analysis support and software solutions for data management and interpretation.

Katrina Waters recently became the Deputy Director for the Biological Sciences Division at the Pacific Northwest National Lab (PNNL). Her expertise is in computational biology, and she works collaboratively with all of the research projects and co-authors with them.

This multidisciplinary training of toxicology students and fellows at OSU and PNNL is a unique strength of our program. Our SRP Trainees have benefited greatly from the PNNL partnership.  Students have gone to the lab in Richland, WA to be trained in Bioinformatics, Statistics and Study Design. More training workshops are being scheduled for this summer and fall.

Waters presented at SOT’s FutureTox II: In Vitro Data and In Silico Models for Predictive Toxicology on January 16, 2014. Her talk was entitled Computational Tools for Integration of High Throughout Screening (HTS) Data. She utilized examples from the collaboration with Robyn Tanguay and his zebrafish assay for toxicity testing (Project 3).

Susan Tilton
Susan Tilton works with Dr. Katrina Waters and the OSU SRP Biostatistics and Modeling Core Group

Dr. Susan Tilton, also from PNNL,  presented at FutureTox as well. The title of her presentation was ‘Pathway-based prediction of tumor outcome for environmental PAH mixtures’.  In this study, they developed a mechanism-based approach for prediction of tumor outcome after dermal exposure to PAHs and environmental PAH mixtures.  Their model was successfully utilized to distinguish early regulatory events during initiation linked to tumor outcome and shows the utility of short-term initiation studies in predicting the carcinogenic potential of PAHs and PAH mixtures.

“Dr. Waters and her group have proven to be of great value in not just the interpretation of extremely large and complicated data sets, but also in the “front-end” study design, which results in enrichment of the subsequent data obtained.”
– Dr. David Williams, OSU SRP Center Director

New Mercury Education Project in Partnership with EPA and Rural School

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This year the EPA Partners in Technical Assistance Program (PTAP) Pilot has launched the first project with a school located near the Black Butte Mine Superfund Site in rural Cottage Grove, Oregon.

“The overall objective of PTAP is to expand opportunities for cooperation between EPA and colleges, universities or nonprofits with the shared goal of assessing and addressing the unmet technical assistance needs of impacted communities. Through PTAP, colleges, universities, and nonprofit organizations cooperate with EPA and voluntarily commit to assist communities with their unaddressed technical assistance needs. At this time, PTAP is in the pilot phase, working with NIEHS Superfund Research Program grantees as PTAP pilot partners. Following this pilot phase, the intention is to expand this project so that any interested colleges, universities or nonprofits may also join the PTAP.”

OSU Superfund Research Program has begun a partnership with EPA through this Pilot to help them expand upon their community outreach capabilities surrounding the Black Butte site.

On December 18, 2013, we met with Laurie Briggs, the Principal of the London School, because she had a strong desire to give her students and their families’ science and environmental health knowledge. About 100 rural K – 8th grade students go to London school.

Our visit included getting to know one another, listening to the needs of the school, and a school tour. We were impressed with the beauty and organization. The school built and maintains a 1/4-acre organic garden, and has a trail to a river flowing behind the property.  72% of the students qualify for free/reduced lunch, and delicious healthy meals are cooked on site.

For this project, we plan to:

1) Maintain communication through monthly meetings, and share notes and project milestones on our web site. [Our next meeting is January 30th, 2014 at OSU.]

2) Address community and educational needs.

  • Create a hands-on, project-based integrated curriculum related to the science of the Superfund site and mercury contamination that can serve as a model for other rural, small schools.
  • Discuss ways to educate the students and community and expand and build a sustainable partnership.

3) Provide training opportunities for SRP Trainees wanting outreach experience.

4) Help students understand career opportunities in environmental and life sciences.

 

 

Project Team from left Diana Rohlman (OSU SRP CEC), Alanna Conley (EPA, Region 10), Dan Sudakin (OSU SRP RTC), Laura Briggs (London School Principle), Naomi Hirsch (SRP RTC OSU). Not pictured: Corey Fisher (OSU SRP CEC), Melissa Dreyfus (EPA Headquarters Superfund Community Involvement Program), Kira Lynch, (EPA Region 10, Science and Tech Liaison), and Richard Muza (Region 10 - Black Butte Mine, Project Manager)
The Project Team from left Diana Rohlman (OSU SRP CEC), Alanna Conley (EPA, Region 10), Dan Sudakin (OSU SRP RTC), Laura Briggs (London School Principal), Naomi Hirsch (OSU SRP RTC). Not pictured: Corey Fisher and Molly Kile (OSU SRP CEC), Melissa Dreyfus (EPA Headquarters Superfund Community Involvement Program), Kira Lynch, (EPA Region 10, Science and Tech Liaison), and Richard Muza (Region 10 – Black Butte Mine, Project Manager)

 

 

 

 

Dr. Paul Slovic Discusses Risk Perception with Graduate Students

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Dr. Paul Slovic
Dr. Paul Slovic

On Oct. 16th, Dr. Paul Slovic visited Oregon State University to share and discuss issues related to risk communication with graduate students enrolled in the TOX 507/607 seminar.  This term the seminar is co-lead by the Superfund Research Center’s Research Translation Core and Training Core.

Dr. Slovic, a founder and President of Decision Research, studies human judgment, decision making, and risk analysis.  His research and expertise fit nicely with this term’s seminar focus on training students to communicate science and risk effectively to audiences outside of academia.

Some key points came out of the Q and A session with Dr. Slovic.

 

 1)  The importance of message framing.

(Reference: Know Your Audience, NWABR)
(Reference: Know Your Audience, NWABR)

After you publish a scientific paper, focus on how you will frame that information to the public.  How can you help your audience conceptualize the bottom line of the research? The facts never speak for themselves, which is why scientists need to “frame” their messages to the public.

All information is conveyed with a frame. Framing in science and risk communication can be viewed as positive or negative depending on who the audience is and what kind of information is

being presented. There is rarely neutral framing.  For that reason, it is important to have a clear message thoughtfully framed to invoke a desirable response by your audience.

Create messages that resonate with your audience.    

2)  The role of emotions and uncertainty.

Understand that risk perception comes from our gut feelings.  How you share information makes a difference, creates an image, and impacts a person’s perception of risk.

Our emotions are often tied to our motivation, positive or negative. Information will lack meaning if it does not invoke emotion.

If something is uncertain, people can interpret it the way that they want. (Example: When scientists began sharing studies that cigarette smoking caused cancer, the tobacco industry wanted to cultivate doubt, so they could keep their profits.). With certain topics, industry and others want to emphasize the unknowns and cast doubt.

When research studies are not definitive, help the public understand the strengths and limitations of that study. Frame the information so it is not biased, focusing on what the science predicts and the implications of that prediction.

 Be sure to present the data the best you can if you think people are distorting the data.

3)  Visuals make research real and relevant. 

Visual images are more powerful than statistics. Visuals help the mind process information. Make your research real and relevant by using visuals that invoke emotion and foster scientific understanding.

slovicgroup
Discussion with Dr. Paul Slovic in the TOX 507/607 seminar on Oct. 16, 2013

Find and share this seminar’s highlights and related articles on Twitter with hashtag #TOX607

Resources

Moving Research Out of the Lab and Into the World

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By Erin Madeen, Project 1 Trainee

ucd.project.madeen[1]
Erin Madeen at the UC Entrepreneurship Academy,
September 17-19, 2013 @ UC Davis
The UC Davis Entrepreneurship Academy was a unique learning experience that teaches the basics of intellectual property as well as marketing and launching a new business. While I am not currently interested in launching a company, this experience provided valuable information on how to maintain flexibility with intellectual property.

As scientists, especially in the SRP, we are always developing new methods and systems to answer our specific questions. Many of those techniques or systems are patentable. Our goal as a federally funded program supported by tax payers is to provide accurate data that can be used to develop environmental policy for a better society. I was not aware that technology used to generate that data is patentable, only in the instance that it was not described in the public domain prior to applying for a patent. Additionally, once a patent has been applied for, the specifics of the technology can be presented in the public domain as a paper, or a presentation.

Also attending the academy were several prior SRP students from UC Davis and UC Berkeley who were able to patent technologies with their respective universities as students and are now launching companies with the technology licensed through the university.

It was an interesting experience to see the traditional binary of industry or academic lines blurred.

ucd.group.madeen[1]
Group photo of the participants at the UC Entrepreneurship Academy with Erin Madeen in the center.

Reducing Exposure & Preserving Cultural Traditions

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The OSU Superfund Center’s Community Engagement Core is fortunate to have an established partnership with the Confederated Tribes of the Umatilla Indian Reservation (CTUIR).

The recently produced CTUIR – OSU 2012-2013 Newsletter shares the background, summary, and findings of a collaborative research project to understand polycyclic aromatic hydrocarbon (PAH) exposure related to smoked salmon.

salmon
Salmon fillet

Salmon, a first food, is important to the subsistence of Native Americans living in the Pacific Northwest. Smoking salmon is one of the traditional ways to preserve this seasonally abundant food and make it available year round.

People can be exposed to PAHs from breathing contaminated air or eating smoked foods although many other exposure pathways exist.

Each volunteer wore air sampling equipment and turned it on every time they went into the smoking structures.

The data showed the air in the tipi and the smoke shed contained PAHs.

tipi        tipifire       smokehouse

Pictured above from left: Traditional tipi, volunteer tending the fire in the tipi wearing an air sampler in black bag on his hip, traditional smoke shed.

The findings from this study were published in the Journal of Agricultural & Food Chemistry.
B, Harris S, Matzke M, Cardenas A, Waters K, Anderson K. (2012). Effect of Native American fish smoking methods on dietary exposure to polycyclic aromatic hydrocarbons and possible risks to human health. Journal of Agricultural & Food Chemistry, 60(27), 6899-6906. doi: 10.1021/jf300978m

Indigenous cultures perceive the natural environment as an essential link between traditional cultural practices, social connectedness, identity, and health. Many tribal communities face substantial health disparities related to exposure to environmental hazards. We asked 27 volunteers who were members of the CTUIR their opinions on meanings of health and how their environment interacts with their health.

The findings from the focus group discussions were published in the journal Environmental Justice.

Schure M, Kile ML, Harding AK, Harper B, Harris S, Uesugi S, Goins T. Perceptions of environment and health among community members of the Confederated Tribes of the Umatilla Indian Reservation.  Environmental Justice. June 2013, 6(3): 115-120. doi:10.1089/env.2013.0022.

In addition, the CTUIR – OSU 2012-2013 Newsletter shares recently appointed members of the Tribal Advisory Board.

We hope you enjoy the newsletter!