{"id":451,"date":"2010-04-13T22:20:41","date_gmt":"2010-04-14T05:20:41","guid":{"rendered":"http:\/\/blogs.oregonstate.edu\/psquared\/?p=451"},"modified":"2010-04-14T00:37:46","modified_gmt":"2010-04-14T07:37:46","slug":"harmonin-a-hearing-protein","status":"publish","type":"post","link":"https:\/\/blogs.oregonstate.edu\/psquared\/2010\/04\/13\/harmonin-a-hearing-protein\/","title":{"rendered":"Harmonin, A Hearing Protein"},"content":{"rendered":"<p>Well, I mentioned that I wanted to choose a protein with some connection to music.\u00a0 After doing a bit of browsing around on Google Scholar, I came across the structural protein harmonin.\u00a0 This protein helps to maintain the structure of stereocillia, the small hairs in the inner ear that detect sound waves and ultimately make hearing possible.<\/p>\n<p><a href=\"http:\/\/blogs.oregonstate.edu\/psquared\/files\/2010\/04\/embor775-f2.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-452\" title=\"embor775-f2\" src=\"http:\/\/blogs.oregonstate.edu\/psquared\/files\/2010\/04\/embor775-f2-300x298.gif\" alt=\"\" width=\"300\" height=\"298\" srcset=\"https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/150\/files\/2010\/04\/embor775-f2-300x298.gif 300w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/150\/files\/2010\/04\/embor775-f2-150x150.gif 150w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/150\/files\/2010\/04\/embor775-f2.gif 600w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>Here is an image of one domain of the protein.\u00a0 It incorporates a decent number of beta strands, but it contains relatively few alpha helices.<\/p>\n<p><a href=\"http:\/\/blogs.oregonstate.edu\/psquared\/files\/2010\/04\/2kbs_asym_r_500.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-454\" title=\"2kbs_asym_r_500\" src=\"http:\/\/blogs.oregonstate.edu\/psquared\/files\/2010\/04\/2kbs_asym_r_500-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/150\/files\/2010\/04\/2kbs_asym_r_500-300x300.jpg 300w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/150\/files\/2010\/04\/2kbs_asym_r_500-150x150.jpg 150w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/150\/files\/2010\/04\/2kbs_asym_r_500.jpg 500w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>I had mentioned that I may consider wrapping guitar strings around drum sticks to form the alpha helices; however, since the helices in this protein are relatively short and drum sticks are very sturdy, I will likely choose something else to form the alpha helices, which will allow me to use drum sticks as part of the scaffold instead.<\/p>\n<p>Materials being considered:<\/p>\n<p>*Guitar strings to represent chains not organized into secondary structures<\/p>\n<p>*Guitar picks, glued end-to-end in an arrow-like fashion, to represent beta strands<\/p>\n<p>*Speaker wire to represent alpha helices (I may swap the role of guitar string and speaker wire, as guitar strings would probably keep the helical shape longer and better)<\/p>\n<p>*Drum sticks as the major structural material (i.e. pillars to hold up the model)<\/p>\n<p>*Saxophone reeds as the minor structural material<\/p>\n<p>*LOTS of Super-Glue!<\/p>\n<p>Let me know what you think!<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Well, I mentioned that I wanted to choose a protein with some connection to music.\u00a0 After doing a bit of browsing around on Google Scholar, I came across the structural protein harmonin.\u00a0 This protein helps to maintain the structure of &hellip; <a href=\"https:\/\/blogs.oregonstate.edu\/psquared\/2010\/04\/13\/harmonin-a-hearing-protein\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1339,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4797],"tags":[],"class_list":["post-451","post","type-post","status-publish","format-standard","hentry","category-student-posts"],"_links":{"self":[{"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/posts\/451","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/users\/1339"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/comments?post=451"}],"version-history":[{"count":2,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/posts\/451\/revisions"}],"predecessor-version":[{"id":456,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/posts\/451\/revisions\/456"}],"wp:attachment":[{"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/media?parent=451"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/categories?post=451"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/tags?post=451"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}