{"id":1401,"date":"2012-05-09T10:41:29","date_gmt":"2012-05-09T17:41:29","guid":{"rendered":"http:\/\/blogs.oregonstate.edu\/psquared\/?p=1401"},"modified":"2012-05-09T15:22:08","modified_gmt":"2012-05-09T22:22:08","slug":"tinkering-on-the-theme-of-a-sandwich","status":"publish","type":"post","link":"https:\/\/blogs.oregonstate.edu\/psquared\/2012\/05\/09\/tinkering-on-the-theme-of-a-sandwich\/","title":{"rendered":"Tinkering on the theme of a sandwich"},"content":{"rendered":"

In the CATH classification system, the “Mainly Beta” parent node (at the C level) has a child node known as “Sandwich<\/a>” (at the A level) whose representative domain structures include over 18,000 known structures. \u00a0That’s a lot of sandwiches.<\/p>\n

Looking through the numerous topological children nodes of Sandwich (at the T level), I notice three representative sandwich topologies that seem especially ripe for being turned into toys by applying a little bit of evolutionarily-inspired tinkering. \u00a0These are the Neurophysin II Chain A topology (CATH code 2.60.9<\/a>) , the ATP synthase epsilon chain domain 1 topology(phew, that’s a mouthful! easier to say CATH code 2.60.15<\/a>), and the Gamma-B crystalline domain 1 topology (CATH code 2.60.20<\/a>).<\/p>\n

What’s fun about these three domain topologies? \u00a0Let’s tinker…<\/p>\n

\"\" \"\"<\/a> \"\"<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

In the CATH classification system, the “Mainly Beta” parent node (at the C level) has a child node known as “Sandwich” (at the A level) whose representative domain structures include over 18,000 known structures. \u00a0That’s a lot of sandwiches. Looking … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4797],"tags":[],"class_list":["post-1401","post","type-post","status-publish","format-standard","hentry","category-student-posts"],"_links":{"self":[{"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/posts\/1401","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/comments?post=1401"}],"version-history":[{"count":6,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/posts\/1401\/revisions"}],"predecessor-version":[{"id":1409,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/posts\/1401\/revisions\/1409"}],"wp:attachment":[{"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/media?parent=1401"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/categories?post=1401"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/tags?post=1401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}