{"id":2721,"date":"2021-03-27T14:56:25","date_gmt":"2021-03-27T21:56:25","guid":{"rendered":"http:\/\/blogs.oregonstate.edu\/psquared\/?page_id=2721"},"modified":"2021-03-28T11:01:51","modified_gmt":"2021-03-28T18:01:51","slug":"protein-folding","status":"publish","type":"page","link":"https:\/\/blogs.oregonstate.edu\/psquared\/protein-folding\/","title":{"rendered":"Protein folding"},"content":{"rendered":"<h2>How chains adopt their three-dimensional shapes<\/h2>\n<p>Protein chains wind around in a 3-D arrangement that is dictated by the character of the amino acids. \u00a0As the amino acids interact, they enforce this shaping of the chain. \u00a0We call this process &#8220;protein folding&#8221;. \u00a0The final shape that is adopted by the protein is generally very complicated. \u00a0Protein scientists use specialized nomenclature to describe the resulting &#8220;protein fold&#8221;. \u00a0Studies of how artificial proteins fold are helping in the discovery of <a href=\"https:\/\/pdb101.rcsb.org\/learn\/structural-biology-highlights\/designer-proteins\">folding rules<\/a>\u00a0and new <a href=\"https:\/\/pdb101.rcsb.org\/motm\/165\">synthetic folding arrangements<\/a> that give us clues about how protein chains naturally fold.<\/p>\n<ul>\n<li>Protein chains often make abrupt turns called &#8220;hairpin turns&#8221;. \u00a0Less abrupt turns are also common. \u00a0Turns allow a protein to fold back upon itself so that we end up with something with a complicated three-dimensional shape.<\/li>\n<li>A few types of regular &#8220;secondary&#8221; structures crop up again and again (alpha helices, beta strands). \u00a0Various sorts of weak interactions (such as hydrogen bonds) add up to help stabilize such secondary structures.<\/li>\n<li>Multiple chains can pack together to give &#8220;multimeric&#8221; proteins. \u00a0A myoglobin molecule, for example, has but one chain. \u00a0A single hemoglobin molecule has four. \u00a0Fibrous proteins (keratin, silk and collagen, for example) are built of many many chains wound together in specialized registries.<\/li>\n<\/ul>\n<p>Take a deep breath. \u00a0There&#8217;s much more &#8230; And that is where artwork (and <a href=\"http:\/\/cbm.msoe.edu\/includes\/modules\/jmolProteinStructure\/index.html\" target=\"_blank\" rel=\"noopener\">computer graphics<\/a>) can really help. \u00a0A good place to tiptoe into computerized display of protein molecules is at <a href=\"http:\/\/pdb101.rcsb.org\/learn\/guide-to-understanding-pdb-data\/molecular-graphics-programs\">PDB-101<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>How chains adopt their three-dimensional shapes Protein chains wind around in a 3-D arrangement that is dictated by the character of the amino acids. \u00a0As the amino acids interact, they enforce this shaping of the chain. \u00a0We call this process &hellip; <a href=\"https:\/\/blogs.oregonstate.edu\/psquared\/protein-folding\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":196,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2721","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/pages\/2721","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/comments?post=2721"}],"version-history":[{"count":5,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/pages\/2721\/revisions"}],"predecessor-version":[{"id":2756,"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/pages\/2721\/revisions\/2756"}],"wp:attachment":[{"href":"https:\/\/blogs.oregonstate.edu\/psquared\/wp-json\/wp\/v2\/media?parent=2721"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}