{"id":2,"date":"2023-12-23T16:49:21","date_gmt":"2023-12-23T16:49:21","guid":{"rendered":"https:\/\/blogs.oregonstate.edu\/higgins\/?page_id=2"},"modified":"2026-02-22T21:09:36","modified_gmt":"2026-02-22T21:09:36","slug":"welcome","status":"publish","type":"page","link":"https:\/\/blogs.oregonstate.edu\/higgins\/","title":{"rendered":"Welcome to the Higgins Lab"},"content":{"rendered":"\n<p>We specialize in biomedical processes and technologies that involve biotransport phenomena, including:<\/p>\n\n\n\n<p>(1) Stabilization of biomolecules, cells, tissues, and organs by cryopreservation or drying, with applications in pharmaceuticals, cell therapy, tissue engineering and organ transplantation.<\/p>\n\n\n\n<p>(2) Microfluidic devices for processing biological fluids, with applications in blood purification and pathogen inactivation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Featured Publications<\/h2>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-9-16 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"The future of organ cryopreservation\" width=\"489\" height=\"869\" src=\"https:\/\/www.youtube.com\/embed\/bQM4HdcmRNY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>Ahmadkhani N, Sugden C, Brown D, Drummond N, Snyder A, Uden M, Higgins AZ, <a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.02.19.706831v1\">A high throughput platform for measuring and predicting vitrification behavior in multicomponent aqueous solutions<\/a>, bioRxiv, 2026.02.19.706831<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"412\" src=\"https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Hamilton-tox-setup-1-1024x412.png\" alt=\"\" class=\"wp-image-87\" srcset=\"https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Hamilton-tox-setup-1-1024x412.png 1024w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Hamilton-tox-setup-1-300x121.png 300w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Hamilton-tox-setup-1-768x309.png 768w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Hamilton-tox-setup-1-1536x618.png 1536w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Hamilton-tox-setup-1-1200x483.png 1200w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Hamilton-tox-setup-1.png 1914w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Ahmadkhani N, Sugden C, Mayo AT, Higgins AZ, <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.05.07.652719v1\">Screening for cryoprotective agent toxicity and toxicity reduction in mixtures at subambient temperatures<\/a>. Cryobiology, 121: 105315, 2025.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"462\" src=\"https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Fig-1-1024x462.jpg\" alt=\"\" class=\"wp-image-90\" srcset=\"https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Fig-1-1024x462.jpg 1024w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Fig-1-300x135.jpg 300w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Fig-1-768x346.jpg 768w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Fig-1-1536x693.jpg 1536w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Fig-1-2048x924.jpg 2048w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Fig-1-1200x541.jpg 1200w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2026\/02\/Fig-1-1980x893.jpg 1980w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Ahmadkhani N, Benson JD, Eroglu A, Higgins AZ. <a href=\"https:\/\/www.nature.com\/articles\/s41598-025-85509-x\">High throughput method for simultaneous screening of membrane permeability and toxicity for discovery of new cryoprotective agents<\/a>. Scientific Reports, 15 (1); 1862, 2025<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"379\" src=\"https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-5-1024x379.jpg\" alt=\"\" class=\"wp-image-31\" srcset=\"https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-5-1024x379.jpg 1024w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-5-300x111.jpg 300w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-5-768x284.jpg 768w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-5-1536x568.jpg 1536w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-5-2048x758.jpg 2048w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-5-1200x444.jpg 1200w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-5-1980x733.jpg 1980w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Warner RM, Yang J, Drake A, Lee Y, Nemanic S, Scott D, Higgins AZ. <a href=\"https:\/\/peerj.com\/articles\/16323\/\">Osmotic response during kidney perfusion with cryoprotectant in isotonic or hypotonic vehicle solution<\/a>. PeerJ. 2023 Nov 21;11:e16323. doi: 10.7717\/peerj.16323. PMID: 38025736; PMCID: PMC10668850.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"627\" src=\"https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-organoid-paper-1024x627.jpg\" alt=\"\" class=\"wp-image-33\" srcset=\"https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-organoid-paper-1024x627.jpg 1024w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-organoid-paper-300x184.jpg 300w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-organoid-paper-768x470.jpg 768w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-organoid-paper-1536x940.jpg 1536w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-organoid-paper-2048x1254.jpg 2048w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-organoid-paper-1200x735.jpg 1200w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-organoid-paper-1980x1212.jpg 1980w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Gulieva RE, Higgins AZ. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0011224021001462?via%3Dihub\">Human induced pluripotent stem cell derived kidney organoids as a model system for studying cryopreservation<\/a>. Cryobiology. 2021 Dec;103:153-156. doi: 10.1016\/j.cryobiol.2021.08.006. Epub 2021 Sep 1. PMID: 34478696.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"483\" src=\"https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-photoreactor-1-1024x483.jpg\" alt=\"\" class=\"wp-image-36\" srcset=\"https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-photoreactor-1-1024x483.jpg 1024w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-photoreactor-1-300x142.jpg 300w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-photoreactor-1-768x363.jpg 768w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-photoreactor-1-1536x725.jpg 1536w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-photoreactor-1-2048x967.jpg 2048w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-photoreactor-1-1200x566.jpg 1200w, https:\/\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/7542\/files\/2023\/12\/Fig-1-photoreactor-1-1980x935.jpg 1980w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Lahmann JM, Faase RA, Leu HY, Jacques SL, Scottoline B, Schilke KF, Baio JE, Higgins AZ. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34853627\/\">Microfluidic photoreactor to treat neonatal jaundice. Biomicrofluidics<\/a>. 2021 Nov 24;15(6):064104. doi: 10.1063\/5.0066073. PMID: 34853627; PMCID: PMC8616629.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We specialize in biomedical processes and technologies that involve biotransport phenomena, including: (1) Stabilization of biomolecules, cells, tissues, and organs by cryopreservation or drying, with applications in pharmaceuticals, cell therapy, tissue engineering and organ transplantation. (2) Microfluidic devices for processing biological fluids, with applications in blood purification and pathogen inactivation. Featured Publications Ahmadkhani N, Sugden [&hellip;]<\/p>\n","protected":false},"author":14007,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/blogs.oregonstate.edu\/higgins\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.oregonstate.edu\/higgins\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.oregonstate.edu\/higgins\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/higgins\/wp-json\/wp\/v2\/users\/14007"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/higgins\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":5,"href":"https:\/\/blogs.oregonstate.edu\/higgins\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":97,"href":"https:\/\/blogs.oregonstate.edu\/higgins\/wp-json\/wp\/v2\/pages\/2\/revisions\/97"}],"wp:attachment":[{"href":"https:\/\/blogs.oregonstate.edu\/higgins\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}