{"id":136,"date":"2021-02-19T18:01:47","date_gmt":"2021-02-19T18:01:47","guid":{"rendered":"https:\/\/blogs.oregonstate.edu\/blouinlab\/?page_id=136"},"modified":"2024-09-23T18:42:47","modified_gmt":"2024-09-23T18:42:47","slug":"snail-schistosome-project","status":"publish","type":"page","link":"https:\/\/blogs.oregonstate.edu\/blouinlab\/snail-schistosome-project\/","title":{"rendered":"Snail\/schistosome project"},"content":{"rendered":"\n
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We study host-parasite compatibility using Biomphalaria glabrata<\/em>, a snail intermediate host for the human pathogen Schistosoma mansoni<\/em>. We use genome wide association mapping methods to discover genes that control variation among snails in resistance to transmitting the parasite. We use various methods to functionally characterize those genes. Example publications below. <\/p>\n<\/div>\n\n\n\n

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Selected papers<\/strong> (for comprehensive list see Publications link above):<\/p>\n\n\n\n

Blouin, MS, SR Bollmann, W Le Clec\u2019h, FD Chevalier, TJC Anderson, and JA. Tennessen. 2024. Susceptibility of BS90 Biomphalaria Glabrata Snails to Infection by SmLE Schistosoma Mansoni Segregates as a Dominant Allele in a Cluster of Polymorphic Genes for Single-Pass Transmembrane Proteins. PLOS Neglected Tropical Diseases<\/em> 18 (9): e0012474. https:\/\/doi.org\/10.1371\/journal.pntd.0012474<\/a>.<\/p>\n\n\n\n

Blouin, MS, SR Bollmann, JA Tennessen. 2022. PTC2<\/em> region genotypes counteract Biomphalaria glabrata<\/em> population differences between M-line and BS90 in resistance to infection by Schistosoma mansoni<\/em> PeerJ<\/em> 10:e13971  https:\/\/doi.org\/10.7717\/peerj.13971<\/a><\/p>\n\n\n\n

Tennessen, JA, SR Bollmann, E Peremyslova, BA Kronmiller, C Sergi, B Hamali and MS Blouin. 2020. Clusters of polymorphic transmembrane genes control resistance to schistosomes in snail vectors. eLife 2020;9:e59395 DOI:10.7554\/eLife.59395<\/a> <\/p>\n\n\n\n

Allan, ERO, JA Tennessen, TJ Sharpton and MS Blouin. 2018.  Allelic variation in a single genomic region alters the microbiome of the snail Biomphalaria glabrata. Journal of Heredity<\/em> esy014,https:\/\/doi.org\/10.1093\/jhered\/esy014<\/a><\/p>\n\n\n\n

Allan, ERO and MS Blouin. 2017. Allelic variation partially regulates galactose-dependent hydrogen peroxide release from circulating hemocytes of the snail Biomphalaria glabrata. Fish and Shellfish Immunology.<\/em> DOI: 10.1016\/j.fsi.2017.10.037<\/p>\n\n\n\n

Allan,  ERO, B. Gourbal, CB Dores, A. Portet, CJ Bayne and MS Blouin. 2017.<\/em>  Clearance of schistosome parasites by resistant genotypes at a single genomic region in Biomphalaria glabrata snails involves cellular components of the hemolymph.  International Journal for Parasitology. <\/em>DOI:10.1016\/j.ijpara.2017.08.008<\/a><\/p>\n\n\n\n

Allen, ERO, JA Tennessen, SR Bollman, PC Hanington, CG Bayne and MS Blouin.  2017. Schistosome defense in the snail, Biomphalaria glabrata<\/em>, is partially dependent on the expression of Grctm6, a Guadeloupe Resistance Complex protein.  PLOS Neglected Tropical Diseases.<\/em> http:\/\/dx.doi.org\/10.1371\/journal.pntd.0005362<\/a><\/p>\n\n\n\n

Tennessen JA, Th\u00e9ron A, Marine M, Yeh JY, Rognon A, Blouin MS 2015 Hyperdiverse gene cluster in snail host conveys resistance to human schistosome parasites. PLoS Genetics <\/em>11(3): e1005067. doi: 10.1371\/journal.pgen.1005067<\/p>\n\n\n\n

Tennessen, JA, KM Bonner, SR Bollman, JA Johnstun, JY Yeh, ML Marine, HF Tavalire, CJ Bayne and MS Blouin. 2015.  Genome-Wide Scan and Test of Candidate Genes in the Snail Biomphalaria glabrata Reveal New Locus Influencing Resistance to Schistosoma mansoni<\/em>.  PLoS Neglected Tropical Diseases, <\/em>9(9): e0004077. doi: 10.1371\/journal.pntd.0004077<\/p>\n","protected":false},"excerpt":{"rendered":"

We study host-parasite compatibility using Biomphalaria glabrata, a snail intermediate host for the human pathogen Schistosoma mansoni. We use genome wide association mapping methods to discover genes that control variation among snails in resistance to transmitting the parasite. We use various methods to functionally characterize those genes. Example publications below. Selected papers (for comprehensive list […]<\/p>\n","protected":false},"author":11174,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-136","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.oregonstate.edu\/blouinlab\/wp-json\/wp\/v2\/pages\/136","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.oregonstate.edu\/blouinlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.oregonstate.edu\/blouinlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/blouinlab\/wp-json\/wp\/v2\/users\/11174"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.oregonstate.edu\/blouinlab\/wp-json\/wp\/v2\/comments?post=136"}],"version-history":[{"count":11,"href":"https:\/\/blogs.oregonstate.edu\/blouinlab\/wp-json\/wp\/v2\/pages\/136\/revisions"}],"predecessor-version":[{"id":320,"href":"https:\/\/blogs.oregonstate.edu\/blouinlab\/wp-json\/wp\/v2\/pages\/136\/revisions\/320"}],"wp:attachment":[{"href":"https:\/\/blogs.oregonstate.edu\/blouinlab\/wp-json\/wp\/v2\/media?parent=136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}