Outline Lecture #5 Spring 2017

Protein Structure

Structure/Function

  • Primary – sequence of amino acids
  • Secondary – interactions between amino acids close in primary sequence
  • Fibrous and Globular Proteins
  • Tertiary Structure HERE
    • Forces – HERE
    • Techniques for determination – X-Ray Crystallography and NMR
    • Example
      • Myoglobin – Heme Oxygen Binding – HEREHERE
    • Denaturation – HERE
    • Refolding – HERE
  • Quaternary Structure

Protein Folding

  • Prediction – HERE
  • Hydrophobicity
  • Aggregation /chaperones – HERE / HERE
  • Prions –HERE

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