Outline Lecture #35 Spring 2017

Nitrogen Metabolism

  • Overview –HERE
  • Nitrogenase Reaction – HERE
  • Nitrogen fixation
  • Regulation of glutamine synthetase – HERE
  • Glutamate/glutamine synthesis – HERE
  • Amino acid synthesis
    • Glutamate family – HERE
    • Aspartate family – HERE
    • Serine family – HERE
    • Pyruvate family – HERE
    • Aromatic family – HERE
    • Histidine family – HERE
  • Relation to citric acid cycle – HERE
  • Pyridoxal phosphate and transamination – HERE
  • Synthesis of serine – HERE
  • Folic acid metabolism and sulfa drugs – HERE
  • Conversion of serine to glycine – HERE
  • Synthesis of cysteine in plants and bacteria – HERE
  • Sulfur and electron transfer in plants and bacteria – HERE
  • SAM – HERE
  • Essential amino acids –TABLE
  • Amino acid catabolism – TABLE
  • Nitrogen products of catabolism – HERE
  • Catabolism of uric acid – HERE
  • Urea cycle – HERE

Purine Metabolism

  • Biosynthesis
    • Atomic origins – HERE
    • AMP and GMP synthesis from IMP –HERE
    • Overview/Regulation of purine biosynthesis – HERE
  • Catabolism – HERE
  • Salvage – HERE / HERE (Lesch-Nyhan syndrome)

Pyrimidine Metabolism

  • Biosynthesis
  • Catabolism – HERE

Deoxyribonucleotide Synthesis

  • Ribonucleotide reductase –HERE
  • Synthesis of thymidine nucleotides HERE
    • Thymidylate synthase reaction – HERE
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