Outline Lecture #29 Spring 2017

Citric Acid Cycle

  • Central Metabolic Pathway – HERE
  • Mitochondrial Structure – HERE
  • Pathway Overview – HERE
  • Entry of Pyruvate

Reactions

  • Oxaloacetate + Acetyl-CoA <=> Citrate + CoASH – HERE
  • Citrate <=> Isocitrate – HERE / Fluorocitrate – HERE
  • Isocitrate + NAD <=> Alpha-ketoglutarate + NADH + CO2 – HERE
  • Alpha-ketoglutarate + NAD + CoASH <=> Succinyl-CoA + NADH + CO2 – HERE
  • Succinyl-CoA + GDP <=> Succinate + GTP + CoASH – HERE
  • Succinate + FAD <=> Fumarate + FADH2 – HERE
  • Fumarate + H2O <=> L-Malate – HERE
  • L-Malate + NAD <=> Oxaloacetate + NADH – HERE

Control of the Cycle – HERE
Energetics – TABLE
Role in Anabolism – HERE

Glyoxylate Cycle

  • Scheme – HERE
  • Isocitrate Lyase Reaction – HERE
  • Malate Synthase Reaction – HERE
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