Outline Lecture #27 Spring 2017

Storage Carbohydrate Metabolism

Gluconeogenesis

  • Pyruvate <=> Oxaloacetate (pyruvate carboxylase) – HERE / HERE
  • Oxaloacetate + GTP <=> PEP + CO2 + GDP (PEPCK) – HERE
  • Scheme of overall pathway – HERE
  • F1,6BP <=> F6P + PO4 (F1,6 bisphosphatase) – HERE
  • G6P <=> Glucose + PO4 (Glucose-6-phosphatase) – HERE
  • Role of F2,6BP – HERE
  • Cori Cycle – HERE
  • Control of Pyruvate Kinase – HERE

Metabolic Control Mechanisms – Allosteric, Covalent, Genetic

Pentose Phosphate Pathway

  • Pathway schematic – HERE
  • Group Transfer Reactions –TABLE

Glycogen Metabolism

Glycogen structure schematic – HERE

  • Breakdown
    • Phosphorolysis to yield G1P – HERE
    • G1P <=> G6P – HERE
    • Debranching – HERE
  • Synthesis
    • UDPG – HERE
    • Glycogen synthase reaction – HERE
    • Branching enzyme – HERE

Regulation

  • Glycogen phosphorylase – HERE
  • Glycogen synthase
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