Outline Lecture #25 Spring 2017

Glycolysis

Overall Scheme

  • Pyruvate fates – HERE
  • Big picture – HERE
  • First Phase – HERE
    • Glucose <=> G6P (Hexokinase) – HERE
      • Hexokinase conformational changes
    • G6P <=> F6P (Phosphoglucoisomerase) – HERE
    • F6P <=> F1,6BP (Phosphofructokinase – PFK) – HERE
      • Allosterism and PFK – HERE
    • F1,6PB <=> DHAP + G3P (Aldolase) – HERE
    • DHAP <=> G3P (Triose phosphate isomerase) – HERE
  • Second Phase – HERE
    • G3P + NAD + PO4 <=> 1,3 BPG + NADH + H+ (Glyceraldehyde-3-phosphate dehydrogenase) – HERE
    • 1,3BPG <=> 3-PG (Phosphoglycerate kinase) – HERE
    • 3-PG <=> 2PG (Phosphoglyceromutase) – HERE
    • 2-PG <=> PEP (Enolase) – HERE
    • PEP <=> Pyruvate (Pyruvate kinase) – HERE
  • Regulation – HERE
  • Anaerobic metabolism
    • Pyruvate <=> Lactate – HERE
    • Alcoholic fermentation – HERE
      • Pyruvate <=> Acetaldehyde (Pyruvate decarboxylase) – HERE
      • Thiamine and TPP = HERE
    • Lactic acid fermentation – HERE
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