Outline Lecture #15 Spring 2017

Replication of Nucleic Acids

Central Dogma – HERE

DNA Replication

  • Semi-Conservative Replication – HERE
  • Bi-Directional Replication – HERE
  • Polymerization by DNA Polymerase – HERE
    • Modified nucleosides as drugs – HERE
  • Replication Fork – HERE (Leading vs. Lagging, Okazaki Fragments)
  • DNA Polymerases of E. coli
    • Properties – TABLE
    • Pol III Holoenzyme Subunits – TABLE
  • Other Proteins for DNA Replication
    • Topoisomerases (Gyrase) – HERE
    • At Replication Fork – HERE
  • Proofreading – HERE
  • DNA Repair
    • Role of exonucleases – HERE
    • Thymine Dimers (nucleotide excision) – HERE / HERE
    • Oxidation Damage (base excision) – HERE
    • Mismatch Repair – HERE
  • Cytosine vs. Thymine vs. Uracil – HERE / HERE
  • Eukaryotes
    • Cell Cycle – HERE
    • DNA Replication Initiation Model – HERE
    • DNA Polymerases – TABLE
    • PCNA
    • Telomerase and Cancer – HERE / HERE / HERE
    • Replication differences – Prokaryotic vs. Eukaryotic – TABLE

Print Friendly, PDF & Email