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Wang Y, Xu X, van Lieshout M, West CE, Lugtenburg J, Verhoeven MA, Creemers AF, Muhilal, van Breemen RB. A liquid chromatography-mass spectrometry method for the quantification of bioavailability and bioconversion of beta-carotene to retinol in humans. Anal Chem. 2000 Oct 15;72(20):4999-5003. doi: 10.1021/ac000454e.

Chen Y, Liu X, Pisha E, Constantinou AI, Hua Y, Shen L, van Breemen RB, Elguindi EC, Blond SY, Zhang F, Bolton JL. A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines. Chem Res Toxicol. 2000 May;13(5):342-50. doi: 10.1021/tx990186j.

Westenburg HE, Lee KJ, Lee SK, Fong HH, van Breemen RB, Pezzuto JM, Kinghorn AD. Activity-guided isolation of antioxidative constituents of Cotinus coggygria. J Nat Prod. 2000 Dec;63(12):1696-8. doi: 10.1021/np000292h.

Henry LK, Puspitasari-Nienaber NL, Jarén-Galán M, van Breemen RB, Catignani GL, Schwartz SJ. Effects of ozone and oxygen on the degradation of carotenoids in an aqueous model system. J Agric Food Chem. 2000 Oct;48(10):5008-13. doi: 10.1021/jf000503o.

Nikolic D, Habibi-Goudarzi S, Corley DG, Gafner S, Pezzuto JM, van Breemen RB. Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration mass spectrometry. Anal Chem. 2000 Aug 15;72(16):3853-9. doi: 10.1021/ac0000980.

Zhang F, Fan PW, Liu X, Shen L, van Breemen RB, Bolton JL. Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone. Chem Res Toxicol. 2000 Jan;13(1):53-62. doi: 10.1021/tx990145n.

Hamm ML, Nikolic D, van Breemen RB, Piccirilli JA. Unconventional origin of metal ion rescue in the hammerhead ribozyme reaction: Mn2+-assisted redox conversion of 2í-mercaptocytidine to cytidine.. J. Am. Chem. Soc. 122, 12069-12078 (2000).

Li W, Gu C, Zhang H, Awang DV, Fitzloff JF, Fong HH, van Breemen RB. Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C. A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng). Anal Chem. 2000 Nov 1;72(21):5417-22. doi: 10.1021/ac000650l.

Gu C, Nikolic D, Lai J, Xu X, van Breemen RB. Assays of ligand-human serum albumin binding using pulsed ultrafiltration and liquid chromatography-mass spectrometry. Comb Chem High Throughput Screen. 1999 Dec;2(6):353-9.

Hadden WL, Watkins RH, Levy LW, Regalado E, Rivadeneira DM, van Breemen RB, Schwartz SJ. Carotenoid composition of marigold (Tagetes erecta) flower extract used as nutritional supplement. J Agric Food Chem. 1999 Oct;47(10):4189-94. doi: 10.1021/jf990096k.

Chung HS, Chang LC, Lee SK, Shamon LA, van Breemen RB, Mehta RG, Farnsworth NR, Pezzuto JM, Kinghorn AD. Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activity. J Agric Food Chem. 1999 Jan;47(1):36-41. doi: 10.1021/jf980784o.

Fu M, Nikolic D, van Breemen RB, Silverman RB. Mechanism of inactivation of g-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid.. J. Am. Chem. Soc. 121, 7751-7759 (1999).

Fast W, Nikolic D, van Breemen R, Marletta MA, Silverman RB. Mechanistic studies of the inactivation of inducible nitric oxide synthase by N5-(1-iminoethyl)-L-ornithine (L-NIO).. J. Am. Chem. Soc. 121, 903-916 (1999).

Nikolic D, Fan PW, Bolton JL, van Breemen RB. Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry. Comb Chem High Throughput Screen. 1999 Jun;2(3):165-75.

Xu X, Wang Y, Constantinou AI, Stacewicz-Sapuntzakis M, Bowen PE, van Breemen RB. Solubilization and stabilization of carotenoids using micelles: delivery of lycopene to cells in culture. Lipids. 1999 Oct;34(10):1031-6. doi: 10.1007/s11745-999-0454-9.

Korecka M, Nikolic D, van Breemen RB, Shaw LM. The apparent inhibition of inosine monophosphate dehydrogenase by mycophenolic acid glucuronide is attributable to the presence of trace quantities of mycophenolic acid. Clin Chem. 1999 Jul;45(7):1047-50.

Zhang F, Chen Y, Pisha E, Shen L, Xiong Y, van Breemen RB, Bolton JL. The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone. Chem Res Toxicol. 1999 Feb;12(2):204-13. doi: 10.1021/tx980217v.

Shen L, Qiu S, Chen Y, Zhang F, van Breemen RB, Nikolic D, Bolton JL. Alkylation of 2′-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical. Chem Res Toxicol. 1998 Feb;11(2):94-101. doi: 10.1021/tx970181r.

Shaw LM, Korecka M, van Breemen R, Nowak I, Brayman KL. Analysis, pharmacokinetics and therapeutic drug monitoring of mycophenolic acid.. Clin. Biochem. 31, 323-328 (1998).

Ito A, Shamon LA, Yu B, Mata-Greenwood E, Lee SK, van Breemen RB, Mehta RG, Farnsworth NR, Fong HHS, Pezzuto JM, Kinghorn AD. Antimutagenic constituents of Casimiroa edulis with potential cancer chemopreventive activity.. J. Agric. Food Chem. 46, 3509-3516 (1998).

van Breemen RB, Nikolic D, Xu X, Xiong Y, van Lieshout M, West CE, Schilling AB. Development of a method for quantitation of retinol and retinyl palmitate in human serum using high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. J Chromatogr A. 1998 Jan 23;794(1-2):245-51. doi: 10.1016/s0021-9673(97)01138-2.

van Breemen RB, Tan Y, Lai J, Huang C-R, Zhao X. Immobilized thymine chromatography-mass spectrometry of oligonucleotides.. J. Chromatogr. A. 806, 67-76 (1998).

Chang M, Zhang F, Shen L, Pauss N, Alam I, van Breemen RB, Blond SY, Bolton JL. Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens. Chem Res Toxicol. 1998 Jul;11(7):758-65. doi: 10.1021/tx9702190.

van Breemen RB, Nikolic D, Bolton JL. Metabolic screening using on-line ultrafiltration mass spectrometry. Drug Metab Dispos. 1998 Feb;26(2):85-90.

Nikolic D, van Breemen RB. Screening for inhibitors of dihydrofolate reductase using pulsed ultrafiltration mass spectrometry. Comb Chem High Throughput Screen. 1998 Apr;1(1):47-55.

Chen Y, Shen L, Zhang F, Lau SS, van Breemen RB, Nikolic D, Bolton JL. The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro. Chem Res Toxicol. 1998 Sep;11(9):1105-11. doi: 10.1021/tx980083l.

Shen L, Pisha E, Huang Z, Pezzuto JM, Krol E, Alam Z, van Breemen RB, Bolton JL. Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity. Carcinogenesis. 1997 May;18(5):1093-101. doi: 10.1093/carcin/18.5.1093.

van Breemen RB. Liquid chromatography/mass spectrometry of carotenoids.. Pure Appl. Chem. 69, 2061-2066 (1997).

Zhang HQ, Dixon RP, Marletta MA, Nikolic D, van Breemen R, Silverman RB. Mechanism of inactivation of neuronal nitric oxide synthase by Nw-allyl-L-arginine.. J. Am. Chem. Soc. 119, 10888-10902 (1997).

van Breemen RB, Huang C-H, Nikolic D, Woodbury CP, Zhao YZ, Venton DL. Pulsed ultrafiltration electrospray mass spectrometry: A new method for screening combinatorial libraries.. Anal. Chem. 69, 2159-2164 (1997).

van Breemen RB, Huang CR, Nikolic D, Woodbury CP, Zhao YZ, Venton DL. Pulsed ultrafiltration mass spectrometry: a new method for screening combinatorial libraries. Anal Chem. 1997 Jun 1;69(11):2159-64. doi: 10.1021/ac970132j.

Shen L, Qiu S, van Breemen RB, Zhang F, Chen Y, Bolton JL. Reaction of the Premarin metabolite 4-hydroxyequilenin semiquinone radical with 2í-deoxyguanosine: Formation of unusual cyclic adducts.. J. Am. Chem. Soc. 119, 11126-11127 (1997).

Zhao YZ, van Breemen RB, Nikolic D, Huang CR, Woodbury CP, Schilling A, Venton DL. Screening solution-phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry. J Med Chem. 1997 Dec 5;40(25):4006-12. doi: 10.1021/jm960729b.

Bolton JL, Pisha E, Shen L, Krol ES, Iverson SL, Huang Z, van Breemen RB, Pezzuto JM. The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells. Chem Biol Interact. 1997 Sep 12;106(2):133-48. doi: 10.1016/s0009-2797(97)00066-5.

van Breemen RB, Huang C-H. High performance liquid chromatography-electrospray mass spectrometry of retinoids.. FASEB J. 10, 1098-1101 (1996).

Van Breemen RB, Huang CR. High-performance liquid chromatography-electrospray mass spectrometry of retinoids. FASEB J. 1996 Jul;10(9):1098-101. doi: 10.1096/fasebj.10.9.8801173.

van Breemen RB. Innovations in carotenoid analysis using liquid chromatography/mass spectrometry.. Anal. Chem. 68, 299A-304A (1996).

van Breemen RB, Huang C-H, Tan Y, Sander LC, Schilling AB. Liquid chromatography/mass spectrometry of carotenoids using atmospheric pressure chemical ionization.. J. Mass Spectrom. 31, 975-981 (1996).

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