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Oregon State University College of Veterinary Medicine eNewsletter

Research Profile: Dr. Jean Hall

May 24th, 2010

Dr. Jean Hall

Dr. Jean Hall earned her B.S. at Oregon State University, then a D.V.M. at Washington State University. She then went to Colorado State University for an M.S and Ph.D.  Her post doctoral work was completed at Oregon Health Sciences University.  Dr. Hall is currently a professor in the College of Veterinary Medicine, Department of Biomedical Sciences, at Oregon State University.

Dr. Jean Hall’s laboratory is performing research studies to determine how nutrition affects immunity. They are interested in nutrigenomic technology, or the study of how nutraceuticals affect the expression of genes involved in the immune response. They have several dog studies in progress to determine whether dietary changes can alter innate immune responses via changes in gene expression. So far, they have shown that phagocytosis by peripheral blood neutrophils and transcript levels of genes involved in neutrophil-mediated functions are decreased in older dogs compared with dogs less than 1 year of age, which may contribute to increased morbidity and mortality with aging. Currently, they are trying to determine if dietary modifications can enhance neutrophil functions, and thus innate immunity, particularly in older dogs.

Metallic selenium

Dr. Hall’s other research projects involve sheep and cows supplemented with selenium (Se) and its effects on the immune response. Selenium has been known to function as a nutrient for over 50 years. However, the dietary requirements of selenium for optimal immune function remain to be determined. In addition, the efficacy of organic versus inorganic sources of selenium has not been thoroughly investigated. Dr. Hall’s goals are to determine if supplementing selenium at levels above those currently recommended can improve innate and adaptive immune responses, and whether organic selenium has increased bioavailability compared to inorganic selenium. Agronomic biofortification is defined as increasing the bioavailable concentration of an essential element in edible portions of crop plants through the use of fertilizers. They are also investigating the potential for using Se-containing fertilizers to increase crop Se concentrations.

This profile can also be found on the “Research Profiles” tab

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